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目的应用复方嗜酸乳杆菌片治疗感染性腹泻,观察微生态制剂对患者胃肠道症状的影响。方法选择100例感染性腹泻患者,均来自青岛大学附属中心医院,采用随机数字表法随机分为A、B组。其中A组患者(80例)单用复方嗜酸乳杆菌片(1.0g/次,3次/d,口服)治疗;B组患者(20例)单用利福昔明片(0.2g/次,4次/d,口服)治疗。两组患者均采用配对设计方法,治疗前进行胃肠道症状分级评分,包括单个症状(腹痛、腹胀、腹泻频率、大便性状)的评分和上述症状的总评分。治疗3d后门诊随访或电话随访,再次进行胃肠道症状分级评分,比较治疗前后患者的胃肠道症状评分改善情况并判断疗效以及治疗中的不良反应。结果两组患者的总有效率分别为78.75%和85.00%,差异无统计学意义(P>0.05)。两组患者治疗过程中均未见不良反应。复方嗜酸乳杆菌片治疗后患者腹胀、腹泻频率、大便性状的症状评分和症状总评分较治疗前显著降低,差异有统计学意义(P<0.01)。腹痛症状评分治疗前后差异无统计学意义(P>0.05)。结论复方嗜酸乳杆菌片治疗感染性腹泻能达到满意的疗效,可改善患者腹胀、腹泻频率、大便性状等胃肠道症状。
Objective To observe the effects of probiotics on gastrointestinal symptoms in patients with infectious diarrhea. Methods A total of 100 patients with infectious diarrhea were selected, all from affiliated hospital of Qingdao University. Randomly divided into A and B groups by random number table. The patients in group A (80 cases) were treated with Lactobacillus acidophilum alone (1.0g / time, 3 times / d, orally); patients in group B (20 cases) were treated with rifaximin alone , 4 times / d, orally) treatment. Paired design was used in both groups to assess GI scores before treatment, including individual symptoms (abdominal pain, abdominal distension, frequency of diarrhea, stool traits) and overall scores for these symptoms. Outpatients were followed up or followed up by telephone for three days. The gastrointestinal symptoms were graded again to compare the improvement of gastrointestinal symptom scores before and after treatment and to determine the efficacy and adverse reactions during treatment. Results The total effective rates of the two groups were 78.75% and 85.00%, respectively, with no significant difference (P> 0.05). No adverse reactions were observed in both groups during treatment. After treatment with compound acidophilus Lactobacillus tablets, the symptoms such as bloating, diarrhea frequency, stool score and symptom score were significantly lower than those before treatment (P <0.01). There was no significant difference in abdominal pain symptom scores before and after treatment (P> 0.05). Conclusion The compound acidophilus Lactobacillus tablets can be used to treat infectious diarrhea with satisfactory curative effect and can improve gastrointestinal symptoms such as abdominal distension, diarrhea frequency and stool character.