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抑制性受体是一类跨膜蛋白,能够减弱或抑制由细胞外到细胞内的信号传递,最终导敛诱导信号的终止。它们大多属于免疫球蛋白超家族,胞内段含有免疫受体酪氨酸抑制基元(ITIM)的共有序列I/VxYxxL,通过ITIM与酪氨酸磷酸酶SHP-1、SHP-2的结合而介导抑制信号。
Inhibitory receptors are a class of transmembrane proteins that attenuate or inhibit signal transduction from the extracellular to the intracellular and ultimately induce the termination of signaling. Most of them belong to the immunoglobulin superfamily. The intracellular domain contains the consensus sequence I / VxYxxL of the immunoreceptor tyrosine inhibitory unit (ITIM). By the combination of ITIM and tyrosine phosphatases SHP-1 and SHP-2 Mediated inhibition signals.