Synthesis and Bioassay of 4-Substituted 2-Oxoglutaric Acids

来源 :中国化学快报（英文版） | 被引量 : 0次 | 上传用户：QQPIG

【摘要】

：

Three 2-oxoglutaric acid analogues were synthesized. Their interaction with factorinhibiting hypoxia-inducible factor (FIH) was studied using LC-MS method. The

【作者】

：

Qiu Yun CHEN Qing Shan LIU Chr

【机构】

：

Department of Chemistry

【出处】

：

中国化学快报（英文版）

【发表日期】

：

2004年期

【关键词】

：

2-Oxoglutatic acid analogues inhibitor

【基金项目】

：

安徽省自然科学基金

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Three 2-oxoglutaric acid analogues were synthesized. Their interaction with factorinhibiting hypoxia-inducible factor (FIH) was studied using LC-MS method. The results show that hydrophobic substitutes of 2-oxoglutaric acids have great influence on their inhibitor activity.

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Synthesis and Bioassay of 4-Substituted 2-Oxoglutaric Acids

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