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就返流性及非返流性胃炎各40例进行胃粘膜组织学特征和胃液成分的对比观察。证示胃液中游离酸、蛋白酶和粘液含量以及胃粘膜的炎症、上皮非典型增生、核分裂、肠上皮化生及腺性囊状扩张等在返流性胃炎中的程度均远比非返流性者为甚,尤以萎缩性胃炎更突出。相关分析显示胃腺萎缩、腺上皮化生和非典型增生等病变的严重情况与粘液和游离酸的降低程度相一致。并表明胃粘膜的急性炎症程度与胃液胆沛酸升高呈正相关,与游离酸和胃蛋白酶含量呈负相关。
Gastric mucosal histological features and gastric fluid components were compared in 40 cases of reflux and non-reflux gastritis. The level of free acid, protease and mucus in gastric juice, gastric inflammation, epithelial dysplasia, nuclear fission, intestinal metaplasia, and glandular cystic dilatation are all significantly higher than those in non-reflux gastritis. Of course, atrophic gastritis is even more prominent. Correlation analysis showed that the severity of lesions such as gastric gland atrophy, glandular epithelial metaplasia, and atypical hyperplasia was consistent with the reduction in mucus and free acid. And it showed that the degree of acute inflammation of gastric mucosa was positively correlated with the elevation of gallbladder acid in gastric juice and negatively correlated with free acid and pepsin content.