论文部分内容阅读
目的探讨中国内地人群类风湿关节炎(RA)与人类白细胞抗原(HLA)-DRB1共同表位(SE)基因的关联情况。方法检索已发表的有关中国内地人群RA和HLA-DRB1的文献,进行汇总分析分析。结果14项研究共纳入1118例RA患者和1301名正常对照,中国内地人群RA的关联基因有HLA-DR4[比值比(OR)=4.05,P<0.0001)]、DRB1*0401(OR=2.66,P=0.004)、DRB1*0404(OR=2.10,P=0.02)、DRB1*0405(OR=3.98,P<0.0001)、DRB1*0410(OR=3.36,P=0.008)、SE(OR=2.75,P<0.00001)。其中DRB1*0405是主要基因亚型。结论汇总分析分析不仅证实了DRB1*0405与中国内地人群RA的关联,而且发现了相对少见基因亚型DRB1*0401、DRB1*0404、DRB1*0410与RA的关联,样本大小对基因关联分析的结论有重要影响。
Objective To investigate the association between human rheumatoid arthritis (RA) and human leukocyte antigen (HLA) -DRB1 common epitope (SE) gene in Chinese mainland. Methods The published literature about published RA and HLA-DRB1 in mainland China were collected and analyzed. Results A total of 1118 RA patients and 1301 normal controls were included in 14 studies. HLA-DR4 (OR = 4.05, P <0.0001) was associated with RA in mainland Chinese subjects, while DRB1 * 0401 (OR = (OR = 3.36, P = 0.008), SE (OR = 2.75, P = 0.004), DRB1 * 0404 (OR = P <0.00001). Which DRB1 * 0405 is the main gene subtype. Conclusion The pooled analysis and analysis not only confirmed the association between DRB1 * 0405 and RA in mainland China, but also found the association between DRB1 * 0401, DRB1 * 0404, DRB1 * 0410 and RA in relatively rare gene subtypes. Have a significant impact.