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肥胖或脂肪酸摄入过剩可使免疫功能发生障碍,1960年曾报道肥胖者感染率增高。动物观察肥胖小鼠胸腺和脾脏的重量减轻,脾脏单核细胞数,Thy1.2-阳性细胞明显降低,但IgM,IgG斑比正常高,自然杀伤(NK)细胞活性增强,抗体依赖性、细胞性细胞毒作用降低,遗传的肥胖小鼠与特异的效应细胞有关。对胖人的观察,正常人术后感染发生率为7.1%,而肥胖者可高达18.1%。20%的肥胖者中性粒细胞机能及CMI(细胞免疫),对念珠菌属,PPD反应等迟发型过敏反应低下,而IgG、IgM、IgA正常。其体外的对PHA,淋巴细胞转化轻度低下,而对照组末梢血免疫球蛋白、补体C_3、C_4值无变化。作者观察肥胖儿的肥胖度由20%增至50%,血清总胆固醇及中性脂肪增加,HDL—胆固醇明显降低,免疫系统指标C_3蛋白明显增加,吞噬细胞受体、诱导异物—C3b—复合体的iC3b机能轻度下降。儿童与成人不同,随着肥胖,免疫蛋白增加,但免疫机能低下。
Obesity or excessive intake of fatty acids can make immune function disorders, obesity in 1960 was reported increased infection rates. The weight of thymus and spleen of obese mice was observed in animals. The number of spleen mononuclear cells and Thy1.2-positive cells were significantly decreased, but the IgM and IgG spots were higher than normal and the activity of natural killer (NK) cells was enhanced. Antibody-dependent, Decreased sexual cytotoxicity, genetic obese mice and specific effector cells. The observation of fat people, the incidence of postoperative infection in normal subjects was 7.1%, while those who were obese up to 18.1%. 20% of obese neutrophil function and CMI (cellular immunity), Candida, PPD response delayed type hypersensitivity reaction is low, and IgG, IgM, IgA normal. In vitro PHA, lymphocyte transformation slightly lower, while the control group of peripheral blood immunoglobulin, complement C_3, C_4 value did not change. The authors observed that the obesity in obese children increased from 20% to 50%, serum total cholesterol and neutral fat increased, HDL-cholesterol significantly decreased, immune system indicators C_3 protein increased significantly, phagocytic receptors, induced foreign body-C3b-complex IC3b function decreased slightly. Children and adults are different, with obesity, increased immune protein, but immune dysfunction.