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小鼠热板法、醋酸扭体法和大鼠光辐射热甩尾法测试,均证实钩吻碱有提高痛阈的作用,小鼠im,sc钩吻碱有增强戊巴比妥钠与水合氯醛的催眠作用。小鼠连续ip钩吻碱5d,未见镇痛作用产生明显的耐受性。小鼠ip钩吻碱连续7次后,不出现sc烯丙吗啡诱发的跳跃反应。小鼠ip钩吻碱无吗啡样S形竖尾反应。钩吻碱对瘾猴的戒断症状,无替代吗啡的作用。ip钩吻碱0.4、0.8、1.0、1.5、2.0mg/kg对醇母致热大鼠无明显解热作用。
The mice hot plate method, the acetic acid writhing method and the rat radiant heat tail flick test all confirmed that the effect of the ghrelin increased the pain threshold. The mice im and sc alkaloids enhanced the pentobarbital sodium and hydration. Hypnotic effects of chloral aldehydes. The mice were continuously ipodated for 5 days, and no analgesic effect was evidently tolerated. After 7 consecutive times of ipocheline in mice, there was no sc morphine-evoked jump reaction. Mouse ipoecine has no morphine-like S-shaped tail reaction. The effect of arginine on withdrawal symptoms in monkeys with addiction has no effect as a substitute for morphine. Ipocheurine 0.4, 0.8, 1.0, 1.5, 2.0 mg/kg had no significant antipyretic effect on alcohol-induced rats.