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目的 了解肝癌和肝硬化患者中TTV DNA感染状况。方法 采用套式PCR技术检测TTV DNA及血清稀释法检测血清TTV DNA的滴度。结果 山东肝癌25例标本中8例TTV DNA阳性,阳性率为32.0％;广州肝癌16例中6例TTV DNA阳性,阳性率为37.5％;广西肝癌65例中28例TTV DNA阳性,阳性率为43.1％。16例肝硬化标本中6例TTV DNA阳性,阳性率为37.5％。结论 研究证实中国肝癌和肝硬化患者中存在35.7％的TTV DNA感染,这种TTV DNA感染是否对肝癌和肝硬化有促进作用,尚待进一步研究证实。
Objective To understand the status of TTV DNA infection in patients with liver cancer and cirrhosis. Methods Titers of TTV DNA and serum dilutions of TTV DNA were detected by nested PCR. Results TTV DNA was positive in 8 of 25 specimens of Shandong hepatocellular carcinoma with a positive rate of 32.0%. Six of 16 liver cancer samples of Guangzhou were positive for TTV DNA, with a positive rate of 37.5%. TTV DNA was positive in 28 of 65 liver cancer specimens from Guangxi 43.1%. TTV DNA was positive in 6 of 16 cirrhotic specimens, with a positive rate of 37.5%. Conclusion The study confirmed that 35.7% of TTV DNA infections exist in patients with liver cancer and cirrhosis in China. Whether this TTV DNA infection can promote liver cancer and liver cirrhosis remains to be confirmed by further studies.