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通过对23例肢端坏死和褥疮患者与10例正常人服用大剂量烟酸前后甲襞微循环观察分析表明,患者都存在着重度甲襞微循环障碍,这种障碍与局部血循环障碍存在着内在的联系.结果提示:烟酸不仅具有较强的扩张周围血管和舒张血管平滑肌作用,还有扩张微血管平滑肌、活跃微循环的作用.治疗后甲襞微循环改善先于周围血循环的好转.随着甲襞微循环恢复,坏死部位疮面逐渐好转直至痊愈.因而对甲襞微循环改变的动态分析,对于本病指导调整用药量、判断疗效等具有指导意义.
Through the 23 cases of acral necrosis and pressure ulcers in patients with 10 normal subjects taking large doses of nicotinic acid before and after nailfold microcirculation observed analysis showed that patients have severe nailfold microcirculation disorder, this disorder and the local blood circulation disorders exist The results suggest that nicotinic acid not only has a strong role in the expansion of the surrounding blood vessels and vasodilator smooth muscle, but also the expansion of microvascular smooth muscle, the role of active microcirculation after treatment of nailfold microcirculation to improve the improvement in the peripheral blood circulation.With Nail loop microcirculation recovery, the necrotic area sore surface gradually improved until healed, so the dynamic changes of nailfold microcirculation, for the disease guide to adjust the dosage, to determine the efficacy and so on.