论文部分内容阅读
通过基于全人群的病例对照谱系调查，应用Ｌｉ－Ｍａｎｔｅｌ－Ｇａｒｔ法和Ｆａｌｃｏｎｅｒ法分别作分离比与遗传率估计。结果表明：（１）一级亲属大肠癌曾患率（‰）分别为：对照组２．７，大肠癌组７．４，结肠癌组９．４，左半结肠癌组９．６，右半结肠癌组６．７，直肠癌组４．９；（２）各先证者组别分离比均显著低于０．２５（在０．０１６～０．０２２之间）；（３）各组一级亲属遗传率明显高于二级亲属；不同先证者一级亲属组间遗传率比较，左半结肠癌组为２８．５％，右半结肠癌组２０．０％，直肠癌组１２．９％。
Based on a population-based case-control pedigree survey, separation ratios and heritability estimates were calculated using the Li-Mantel-Gart method and the Falconer method. The results showed that: (1) The prevalence of primary colorectal cancer (‰) was 2.7 in the control group, 7.4 in the colorectal cancer group, 9.4 in the colon cancer group, 9.6 in the left colon cancer group, and the right half. Colon cancer group 6.7, rectal cancer group 4.9; (2) Separation ratio of each proband group was significantly lower than 0.25 (between 0.016 to 0.022); (3) each group The heritability of the first-degree relatives was significantly higher than that of the second-degree relatives; the heritability of the first-degree relatives of different probands was 28.5% for the left-sided colon cancer group, 20.0% for the right-sided colon cancer group, and 12 for the rectal cancer group. .9%.