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近年来，糖尿病相关并发症越来越受到关注，在眼部主要影响角膜和视网膜。玻璃体切割术的普及使糖尿病角膜病变引起大家的广泛关注。高血糖可通过改变角膜形态、代谢和生理影响角膜各层次结构，影响角膜上皮、角膜神经、泪膜，甚至影响角膜内皮和结膜的正常功能，导致角膜上皮迁延不愈，持续性水肿，复发性糜烂，角膜神经敏感性下降和泪膜改变等。现笔者主要探讨糖尿病角膜病变的形态学和病理学改变，相关的发病机制以及目前正在研发的实验性治疗药物，希望对临床诊疗有所助益。“,”In recent years, diabetes-related complications have received increasing attention, mainly affecting the cornea and retina in the eye. The popularity of vitrectomy has caused concern of diabetic keratopathy. Hyperglycemia can affect corneal hierarchy by changing corneal morphology, metabolism and physiology, affecting the corneal epithelium, corneal nerve, tear film, and even the normal function of corneal endothelium and conjunctiva, leading to corneal epithelial elongation, persistent edema, recurrent erosion, decreased corneal nerve sensitivity, and tear film changes. This paper mainly discusses the morphological and pathological changes of diabetic keratopathy, the related pathogenesis and the experimental therapeutic agents currently under research, hoping to be helpful for clinical treatment.