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24例妇女肌注炔诺酮庚酸酯200 mg,肌注前血清性激素结合球蛋白(SHBG)为53.32±23.23 nmol╱L。注射后5天为41.99±17.06nmol/L(P<0.05),21天降至最低值14.72±10.01 nmol/L,以后逐渐回升,直至注射后84天仍未回复到原来水平(34.46±20.39 nmol/L)。10例妇女单次口服18甲基炔诺酮6 mg+炔雌醚3 mg,服药前血清SHBG水平为42.76±13.89 n mol/L,服药后7天为62.53±10.90 nmol/L(P<0.01),14天达峰值为71.33±5.77 nmol/L,以后持续此高水平,直至服药后56天;8例连续3次口服18甲+炔雌醚,每次间隔23天,服药前血清SHBG水平为44.94±15.36 nmol/L,第1次服药后9天为83.46±10.08 nmol/L(P<0.01),16天达峰值为91.74±2.28nmol/L,以后持续高水平直至第3次服药后30天,第2、3次重复给药对业已升高的SHBG水平无影明显响。第2、3次服药后LNG峰值明显高于首次服药后峰值6倍。
Twenty-four women received norethindrone acetate 200 mg intramuscularly and 53.32 ± 23.23 nmol ╱ L before the intramuscular injection of SHBG. 41.99 ± 17.06nmol / L (P <0.05) on the 5th day after injection and 14.72 ± 10.01nmol / L on the 21st day after injection, and then gradually rose until 84 days after injection (34.46 ± 20.39 nmol / L). In 10 women, the level of SHBG was 42.76 ± 13.89 n mol / L before treatment and 62.53 ± 10.90 nmol / L (P <0.01) on the 7th day after taking 18 mg of norethindrone 6 mg and ethynylestradiol respectively. , The peak value on the 14th day was 71.33 ± 5.77 nmol / L, and then continued to the high level until 56 days after taking the drug. In the 8 cases, oral administration of 18 A + ethynylestradiol for 3 days continuously for 23 days, the serum SHBG level 44.94 ± 15.36 nmol / L, 83.46 ± 10.08 nmol / L at 9 days after the first dose (P <0.01), reached the peak at 91.74 ± 2.28 nmol / L on the 16th day after the third dose Day, the second and third repeated administration had no obvious effect on the elevated SHBG level. The peak value of LNG after the 2nd and 3rd doses was significantly higher than the peak value of 6 times after the first dose.