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目的:探讨不同剂量的丙种球蛋白对于治疗小儿川崎病冠状动脉病变的临床效果。方法:选择在我院接受治疗的川崎病冠状动脉病变患儿76例,将其随机分为A、B、C三组,A组患儿给予单次剂量为1g/kg的丙种球蛋白(IVIG)静脉滴注,B组患儿给予单次剂量为2g/kg的丙种球蛋白(IVIG)静脉滴注,C组患儿给予丙种球蛋白静脉滴注,剂量为0.4g(/kg·d),持续用药5d;观察、比较三组患儿的川崎病冠状动脉病变临床治疗及病变缓解情况。结果:在临床症状缓解方面:A、B组临床症状缓解时间明显短于C组(P<0.05);在冠状动脉病变恢复方面,各组无显著差异(P>0.05);而在IVIG耐药率方面,C组明显高于A、B两组。结论:不同剂量的丙种球蛋白治疗川崎病冠状动脉病变,其症状缓解和冠状动脉病变恢复情况均有所不同,应综合考虑使用剂量,建议采用单次滴注丙种球蛋白治疗的方式。
Objective: To investigate the clinical effects of different dosages of gamma globulin on coronary artery lesions in children with Kawasaki disease. Methods: Sixty-six children with Kawasaki disease who were treated in our hospital were randomly divided into three groups (A, B and C). A group received single dose of 1g / kg gamma globulin ), Intravenous infusion of B group of children given a single dose of 2g / kg intravenous infusion of gamma globulin (IVIG), C group given intravenous gamma globulin, a dose of 0.4g (/ kg · d) , Continuous medication 5d; observed, compared three groups of children with Kawasaki disease clinical treatment and lesion relief. Results: In the aspect of clinical symptom relief, the clinical symptom relief time in group A and B was significantly shorter than that in group C (P <0.05); in the recovery of coronary artery disease, there was no significant difference among groups (P> 0.05) Rate, C group was significantly higher than A, B two groups. Conclusion: Different dosages of gamma globulin in treatment of coronary artery lesions in Kawasaki disease, its symptoms and coronary lesions recovery are different, should be taken into account the dosage, it is recommended to adopt a single infusion of gamma globulin treatment.