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急性呼吸道感染占小儿发病率的首位,反复呼吸道感染(简称 RAI)对小儿健康危害甚大。经免疫测定,反复呼吸道感染的患儿(简称复感儿)血浆中 IgG、IgA 水平明显高于健康儿童,而 IgM 却比健康儿童低得多,表明复感儿的红细胞免疫功能低下,体液免疫功能紊乱。因此,除了抗菌治疗外,提高机体免疫功能也是防治 RAI 的重要途径。近年来,有关这方面的免疫增强剂报告很多,本文综合了部分资料,归纳如下:1.1 丙种球蛋白γ-Globulin(IgG) 杨锡强报道,血清中 IgG 亚类缺陷与 RAI 密切相关。抗菌治疗无效或严重病例是采用丙种球蛋白替代治疗的指征,静注丙种球蛋白制剂的疗效明显优于肌注。该制剂应含有与正常人血清相同比例的各 IgG 亚类。用量一般为每月200～400mg/kg。
Acute respiratory infections account for the highest incidence of pediatric infections, recurrent respiratory tract infections (referred to as RAI) on children’s health hazards. Immunoassay, recurrent respiratory tract infection in children with recurrent respiratory tract infection in children with plasma IgG, IgA levels were significantly higher than healthy children, while IgM was much lower than healthy children, indicating that recurrent children with erythrocyte immune dysfunction, humoral immunity Dysfunction. Therefore, in addition to antimicrobial therapy, to improve immune function is also an important way to prevent and treat RAI. In recent years, there are a lot of reports on immune enhancers in this area. Some of the data are summarized in this article. The results are summarized as follows: 1.1 Gamma Globulin (IgG) 1.1 It is reported by Yang Xiqiang that IgG subclass deficiency in serum is closely related to RAI. Antibacterial therapy is invalid or serious cases of gamma globulin alternative treatment indications, intravenous gamma globulin preparation was significantly better than intramuscular injection. The preparation should contain the same IgG subclasses as normal human serum. The dosage is generally 200 ~ 400mg / kg per month.