目的探讨妊娠期肝内胆汁淤积症(ICP)对母婴的危害。方法对2003年1月~2006年8月在我院分娩的伴有黄疸及其他脏器功能不全的12例ICP母婴死亡病例进行回顾性分析。结果ICP患者伴有黄疸及其他脏器功能不全时,极易在短期内引起母婴死亡。结论ICP伴有合并症时对母婴危害极大,应加强围生期保健工作。 Objective To investigate the risk of intrahepatic cholestasis of pregnancy (ICP) to maternal and infant. Methods A retrospective analysis of 12 cases of maternal and neonatal deaths with jaundice and other organ dysfunction in our hospital from January 2003 to August 2006 was performed. Results ICP patients with jaundice and other organ dysfunction, easily lead to maternal and infant deaths in the short term. Conclusion ICP with comorbidities is extremely harmful to mothers and infants, should be strengthened perinatal care.