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Cajal间质细胞(interstitial cells of cajal,ICC)主要分布在胃肠道平滑肌细胞与神经纤维之间,是一类特殊的间质细胞,它是胃肠运动的起搏细胞,具有产生、传导慢波,调节胃肠道平滑肌运动的功能。而慢性假性肠梗阻是由于胃肠神经抑制,毒素刺激或肠壁平滑肌本身病变,导致的肠壁肌肉运动功能减弱,临床上具有肠梗阻的症状和体征,但无肠内外机械性肠梗阻因素存在,故又称动力性肠梗阻,按病程有急性和慢性之分,麻痹性肠梗阻和痉挛性肠梗阻属于急性假性肠梗阻,深入研究Cajal间质细胞,对进一步认识胃肠运动的生理及胃肠动力疾病的发生机制有重要意义。
Interstitial cells of cajal (ICC) are mainly distributed between gastrointestinal smooth muscle cells and nerve fibers. They are a kind of special interstitial cells. They are the pacemaker cells of gastrointestinal motility and have the characteristics of producing, Wave, regulating gastrointestinal smooth muscle function. The chronic pseudo-intestinal obstruction is due to gastrointestinal nerve inhibition, toxin stimulation or intestinal wall smooth muscle lesions, resulting in reduced intestinal muscle motor function, clinical symptoms and signs of intestinal obstruction, but no mechanical intestinal obstruction intestinal factors Exist, it is also known as dynamic intestinal obstruction, according to the course of acute and chronic points, paralytic ileus and spastic intestinal obstruction belongs to acute pseudo intestinal obstruction, in-depth study of interstitial cells of Cajal, to further understand the physiological gastrointestinal motility And gastrointestinal motility mechanism is of great significance.