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目的观察连花清瘟颗粒联合α1b干扰素治疗手足口病的疗效和安全性。方法将168例手足口病患儿随机分为连花清瘟颗粒组(A组52例)、α1b干扰素组(B组55例)和连花清瘟颗粒联合α1b干扰素组(C组61例),观察发热,疱疹结痂和消退时间,转型病例数、肠道病毒转阴时间及住院天数。结果连花清瘟颗粒联合α1b干扰素在疱疹结痂和消退时间、肠道病毒转阴时间、平均住院天数均优于其他两组(P<0.01),而转型例数无统计学意义(P>0.05),也未发现其他副作用。结论连花清瘟颗粒联合α1b干扰素治疗手足口病疗效确切安全。
Objective To observe the efficacy and safety of Lianghua Qingwen granule combined with α1b interferon in the treatment of hand, foot and mouth disease. Methods 168 children with HFMD were randomly divided into two groups: Lianhua Qingwen Granule Group (Group A, 52 cases), α1b Interferon Group (Group B, 55 cases) and Lianghua Qingwen Granule combined with α1b Interferon Group (Group C 61 Cases), observed fever, herpes scab and subsided time, the number of cases of transformation, enterovirus negative time and hospitalization days. Results Lianghua Qingwen granule combined with α1b interferon was better than the other two groups in the time of herpes scabbing and extinction, the time of enterovirus negative conversion and the average length of stay in hospital (P <0.01), but there was no statistical significance > 0.05), also found no other side effects. Conclusions Lianghua Qingwen granule combined with α1b interferon is safe and effective in the treatment of HFMD.