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目的 评价单纯放疗与化放疗对不能手术 期非小细胞肺癌 (Non Small Cell L ung Cancer,NSCL C)的疗效 .方法 113例不能手术的 期 NSCL C患者分为两组 :5 7例采用 CAP方案 (环磷酰胺 ,阿霉素、顺铂 )联合化疗 ,2～ 4疗程后给予放疗 . 5 6例患者接收单纯放疗 .两组的放疗方式和剂量相同 ,均采用常规分割放射 ,每次 1.8～ 2 .0 Gy,5次 / wk.原发病灶及肿瘤转移部位的总剂量 (Dose of Tum or,DT)为 6 0～ 70 Gy,淋巴引流区 DT为 5 0 Gy.结果 化放组总有效率为6 6 .7% ,完全缓解 (Com plete Response,CR)为 14.0 % ,中位生存期 13mo;单纯放疗的总有效率为 5 7.1% ,CR5 .4% ,中位生存期 8mo.两组的总有效率无差别 (P>0 .0 5 ) ,但生存期有显著差异 (P<0 .0 5 ) .化疗的副作用主要是胃肠反应及骨髓抑制 ,两组放疗的副反应相似 ,主要是放射性肺炎及肺纤维化 .结论 不能手术 期 NSCL C化放疗的 1a生存率及中位生存期优于单纯放疗 ,而放化疗的毒副作用患者是可耐受的
Objective To evaluate the efficacy of radiotherapy and chemoradiotherapy alone in the treatment of non-small cell lung cancer (NSCL C) .Methods A total of 113 patients with inoperable NSCL C were divided into two groups: 57 patients underwent CAP regimen (Cyclophosphamide, doxorubicin, cisplatin) combined with chemotherapy, after 2 to 4 courses of radiotherapy .5 6 patients received simple radiotherapy .Two groups of radiotherapy methods and doses are the same, are used routine split radiation, each 1.8 ~ 2.0 Gy, and 5 times / wk.The total dose (Dose of Tum, DT) of primary lesion and tumor metastasis was 60 ~ 70 Gy, and the DT of the drainage area was 50 Gy.Results The total The effective rate was 6.6%, the CR was 14.0%, and the median survival time was 13 months. The total effective rate of radiotherapy alone was 51.1%, CR5.4%, and the median survival time was 8 months. The total effective rate was no difference (P> 0.05), but the survival was significantly different (P <0.05) .The side effects of chemotherapy were mainly gastrointestinal reactions and myelosuppression, side effects of radiotherapy were similar , Mainly radioactive pneumonitis and pulmonary fibrosis.Conclusion The survival rate and median survival time of non-operative NSCL C radiotherapy Superior to radiotherapy alone, while the side effects of radiotherapy and chemotherapy in patients is tolerable