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目的：评价国产和进口氟西汀治疗卒中后抑郁症的疗效和安全性。方法：将１０４例患者随机分为国产和进口氟西汀组各５２例，均ｐｏ２０ｍｇ／ｄ，治疗６周。采用Ｈａｍｉｌｔｏｎ抑郁量表、临床总体印象量表和药物不良反应评定量表评定疗效和药物不良反应。结果：治疗６周末，国产与进口氟西汀的显效率分别为８４．６２％和８６．５４％（Ｐ＞０．０５）。两组主要不良反应均为轻微的恶心、食欲减退和厌食。结论：国产和进口氟西汀治疗卒中后抑郁症同样有效、安全。
Objective: To evaluate the efficacy and safety of domestic and imported fluoxetine in the treatment of post-stroke depression. Methods: 104 patients were randomly divided into domestic and imported fluoxetine group 52 cases, both po20mg / d, for 6 weeks. The Hamilton Depression Inventory, Clinical Impression Scale and Adverse Drug Reaction Rating Scale were used to evaluate the efficacy and adverse drug reactions. Results: After six weeks of treatment, the effective rates of domestic and imported fluoxetine were 84.62% and 86.54%, respectively (P> 0.05). The two major adverse reactions were mild nausea, loss of appetite and anorexia. Conclusion: Both domestic and imported fluoxetine are equally effective and safe in treating post-stroke depression.