Selective alkylation of aldehydes by allyl bromide and tin

来源 :Acta Chimica Sinica(English Edition) | 被引量 : 0次 | 上传用户:wdxf365
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It has been reported that allylic organotin compounds,such as tributylcrotyl tin,reactedwith carbonyl compounds to give correspon djng homoallyl alcohols.It was also foundthat allyl bromide and tin powder jn tetrahydrofuran(THF)can be directly used in this reac-tion,and a small amount Of water seems to be accelerating.In this paper we report thedirect,selective allylation of aldehydes which contain hydroxy,phenolic hydroxy,aromaticnitro,bromo or alkylketo group by allyl bromide and powdered tin,without the protection It has been reported that allylic organotin compounds, such as tributylcrotyl tin, formed mixtures of djng homoallyl alcohols. It was also found that allyl bromide and tin powder jn tetrahydrofuran (THF) can be directly used in this reac- tion, and a small amount Of water seems to be accelerating. In this paper we report the direct, selective allylation of aldehydes which contain hydroxy, phenolic hydroxy, aromatic nitrides, bromo or alkylketo groups by allyl bromide and powdered tin, without the protection
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