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目的：检测肠上皮化生、不典型增生的胃粘膜组织和胃癌组织中间隙连接蛋白Connexin32（Cx32）的表达，探讨其变化规律及意义。方法：应用免疫组化染色S－P法对21例肠上皮化生、19例不典型增生和32例胃癌标本间隙连接蛋白Cx32表达进行研究。结果：肠上皮化生、不典型增生和胃癌组织中均有不同程度的Cx32表达，但同正常胃粘膜相比，Cx32阳性率明显下降（P＜0．05），在胃癌组织中，Cx32只表达在粘膜下层和肌层的肿瘤细胞内，粘膜层的肿瘤细胞内未见阳性着色。结论：间隙连接可能参与了胃癌发生。
Objective: To detect the expression of connexin32 (Cx32) in intestinal metaplasia, dysplasia gastric mucosa and gastric carcinoma, and to explore its variation and significance. Methods: The expression of connexin Cx32 in 21 cases of intestinal metaplasia, 19 cases of atypical hyperplasia and 32 cases of gastric cancer was studied by immunohistochemical S-P method. Results: The expression of Cx32 in intestinal metaplasia, atypical hyperplasia and gastric cancer tissues were all significantly different, but the positive rate of Cx32 was significantly lower than that in normal gastric mucosa (P <0.05). In gastric carcinoma, Cx32 Expression in the submucosa and myometrial tumor cells, mucosal layer of tumor cells in the absence of positive staining. Conclusion: Gap junction may be involved in gastric carcinogenesis.