目的:对骨髓侵犯非霍奇金淋巴瘤患者的淋巴瘤细胞形态进行分析。方法:对243例病理上确诊的非霍奇金淋巴瘤患者进行骨髓涂片,分析其形态学改变。结果:243例中发生侵犯40例,侵犯率为16.5%,其中淋巴瘤细胞骨髓浸润27例(67.5%);淋巴瘤细胞白血病13例(32.5%)。总体上瘤细胞异形性明显,胞体大小不等,核明显畸形,易见到双核或多核,核染色质较粗而密,核仁可见或不见,胞质量少,染色偏碱性。结论:骨髓涂片观察瘤细胞形态,不仅可确定瘤细胞浸润程度,而且可分辨淋巴瘤细胞类型。 OBJECTIVE: To analyze the morphology of lymphoma cells in patients with non-Hodgkin lymphoma with bone marrow invasion. Methods: A total of 243 patients with pathologically confirmed non-Hodgkin’s lymphoma were treated with bone marrow smears and their morphological changes were analyzed. Results: Of the 243 cases, 40 cases were infringed and the rate of infiltration was 16.5%. Among them, 27 cases (67.5%) were infiltrated with lymphoma cells and 13 cases (32.5%) with lymphoma cell leukemia. On the whole, the abnormality of the tumor cells was obvious. The sizes of the somatic cells were unequal. The nuclei showed obvious deformities. It was easy to see binuclear or multinuclear. The chromatin of the nucleus was thick and dense, the nucleoli were visible or not, the cytoplasm was less and the staining was more alkaline. Conclusion: Bone marrow smear observation of tumor cell morphology, not only to determine the extent of tumor cell infiltration, but also to distinguish the type of lymphoma cells.