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目的 探讨血管中心性淋巴瘤的临床特点及治疗。方法 分析我院自 1993年 11月至 1999年 3月期间收治的 2 0例血管中心性淋巴瘤。结果 该病的发病率占同期非何杰金淋巴瘤的 2 .3 % ,首发于结外部位占 85 % ,依次为鼻腔、软组织、皮肤、鼻咽、喉、硬腭、睾丸、牙龈 ,大多表现为肿块和溃疡 ,诊断时即为广泛播散者 (Ⅳ期 )占 5 0 % ,化疗和 /或放疗CR率 3 5 .3 % ,总有效率 5 8.8% ,1例Ⅰ期患者单用放疗已无病生存 4年 ,1例Ⅳ期患者单用化疗已无病生存5年。结论 血管中心性淋巴瘤晚期、结外器官侵犯者多 ,强烈化疗和 /或放疗可获持久的完全缓解。
Objective To investigate the clinical features and treatment of vascular central lymphoma. Methods Twenty cases of angiocentric lymphoma treated in our hospital from November 1993 to March 1999 were analyzed. Results The incidence of this disease accounted for 2.3% of non-Hodgkin’s lymphoma in the same period, with 85% starting from the extranodal site, followed by nasal cavity, soft tissue, skin, nasopharynx, larynx, hard palate, testes and gums. For the masses and ulcers, diagnosis of broad disseminators (stage Ⅳ) accounted for 50%, chemotherapy and / or radiotherapy CR rate of 35.3%, the total effective rate of 8.88%, a case of stage Ⅰ patients with radiotherapy alone Has been disease-free for 4 years, 1 case of stage IV chemotherapy alone has been disease-free survival of 5 years. Conclusions Advanced vascular central lymphoma, extranodal organ invasion more, strong chemotherapy and / or radiotherapy can achieve lasting complete remission.