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目的:通过对稳定期慢性阻塞性肺疾病(COPD)患者的肺功能等指标进行为期1年的前瞻性随访观察,了解稳定期COPD患者1年前后的肺功能的变化,探讨利用肺功能评估COPD病情的临床意义。方法:对40例稳定期COPD患者进行为期1年的随访观察,共38例完成随访。对入选患者进行健康教育和药物治疗指导。观察稳定期COPD患者在1年前后肺功能、经皮血氧饱和度(SpO2)、Borg呼吸困难和Borg疲劳评分等指标的动态变化。结果:在随访结束时同入选时比较,心率、呼吸频率、SpO2、Borg呼吸困难和疲劳程度评分均无显著变化(P>0.05)。同入选时比较,肺功能指标在1年随访结束时,FEV1占预计值%、FEV1/FVC、FEF50占预计值%和DLCO占预计值%显著增加(P<0.05),R5占预计值%显著下降(P<0.05),而用力肺活量占预计值百分比等其他肺功能指标无明显变化(P>0.05)。结论:稳定期COPD患者在为期1年随访的前后,肺功能指标FEV1、FEV1/FVC、DLCO、FEF50和R5有所好转,Borg呼吸困难和Borg疲劳评分无显著变化。
OBJECTIVE: To investigate the change of lung function in patients with stable COPD one year ago after a one-year prospective follow-up observation of lung function and other indicators in patients with stable chronic obstructive pulmonary disease (COPD), and to explore the use of pulmonary function assessment of COPD The clinical significance of the disease. Methods: Forty patients with stable COPD were followed up for one year. A total of 38 patients were followed up. The selected patients for health education and medication guidance. To observe the dynamic changes of lung function, SpO2, Borg dyspnea and Borg fatigue scores in patients with stable COPD at one year ago. RESULTS: Heart rate, respiratory rate, SpO2, Borg dyspnea and fatigue scores did not change significantly at the end of follow-up (P> 0.05). At the end of the one year follow-up, FEV1 accounted for% of predicted, FEV1 / FVC, FEF50% of predicted and DLCO% predicted (P <0.05), and R5 accounted for% of predicted (P <0.05). However, other lung function indexes such as forced vital capacity (%) of predicted value did not change significantly (P> 0.05). Conclusion: Before and after a one-year follow-up of stable COPD patients, FEV1, FEV1 / FVC, DLCO, FEF50 and R5 improved, Borg dyspnea and Borg fatigue scores did not change significantly.