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比较观察了半胱氨酸(Cys),N-乙酰半胱氨酸(NAC)及胱胺(CSSC)对Langendorff灌流大鼠心脏缺血再灌所致心功能低下的保护作用。心脏平衡后开始给药(3.6μmol/min)直至实验结束。Cys和NAC可使心脏缺血再灌后的LVP、±dP/dt和RPP迅速恢复至结扎前的水平,并显著高于生理盐水对照组,CSSC则未见有这些保护作用。三药均可使结扎期的冠脉流量明显高于对照。所试药物对Fenton反应生成的OH均有不同程度的清除,Cys的效果最强。
The protective effects of Cys, NAC and CSSC on cardiac dysfunction caused by ischemia reperfusion in Langendorff perfusion rats were observed. After the heart is balanced, administration (3.6 μmol / min) is started until the end of the experiment. Cys and NAC rapidly restored LVP, ± dP / dt and RPP after myocardial ischemia and reperfusion to pre-ligation levels, and were significantly higher than those in saline control group. These protective effects were not observed in CSSC. Three drugs can make the ligation of coronary flow was significantly higher than the control. The drugs tested to OH generated by Fenton reaction were cleared to varying degrees, Cys the strongest.