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Objective: The aim of our study was to investigate the value of CT/CT image fusion radiation treatment planning in non-small cell lung cancer (NSCLC) and the impact on V20 and radiation pneumonitis (RP). Methods: Patients who were pathologically or cytologically diagnosed of stage IIIA and IIIB NSCLC were treated with three-dimensional conformal radiation therapy (4000 cGy). Forty patients got at least 25% tumor reduction were randomly divided into two groups: group A of regular shrink field radiotherapy (20 cases) and group B of CT/CT image fused shrink field radiotherapy (20 cases). Dosage reached 6600 cGy. Clinical data, V20 and RP were observed within 3 months after radiotherapy. Statistical analysis was conducted for the NSCLC patients. Results: 22.5% (9/40) patients got RP during follow-up. Group A accounted for 6 cases (30%), and group B had 3 cases (15%). There was no marked difference between the two groups (P = 0.256), univariate analysis revealed that the IV20 of A and B groups, and IV20 and CV20 of all patients were statistically related to the incidence of RP (P < 0.05). With Wilcoxon method assay, the ipsilateral lung V20 and contralateral lung V20 had statistical significance between the two groups (P < 0.05). Conclusion: The CT/CT image infusion treatment planning could increase the radical dosage with better tumor control probability but wont increase adverse reaction.