【摘 要】
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OBJECTIVE:To investigate the mechanism under-pinning the effect of Chaihu Shugan San(柴胡疏肝散,CHSGS)on major depressive disorder(MDD).METHODS:We searched the
【机 构】
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Clinical basic teaching and Research Office of Tradi-tional Chinese Medicine,Chengdu University of T
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OBJECTIVE:To investigate the mechanism under-pinning the effect of Chaihu Shugan San(柴胡疏肝散,CHSGS)on major depressive disorder(MDD).METHODS:We searched the compound compo-nents of from seven herbal ingredients of CHSGS from TCMSP,SymMap,ETCM,NPASS databases,and the chemical structure of the compound from Pub-Chem,and collected the compound targets from TCMSP and TargetNet databases,and MDD-related targets from DiseaseGene Network.We established protein-protein interaction in the STRING database.Through gene mapping,topology analysis and en-richment analysis,the core targets and pathways of CHSGS for MDD,and the involved biological pro-cesses(BP),cell components(CC),and molecular functions(MF)were predicted.RESULTS:We collected a total of 1135 CHSGS com-pounds.After screening by ADME standards and the five rules of Ribinski,we obtained 99 different chemical components with different chemical structures,and related targets of 183 different CHSGS compounds.In the DiseaseGene Network,a total of 740 relevant targets for MDD were collect-ed.Through gene mapping and topological analy-sis,62 related targets of CHSGS for MDD,24 targets with topological Chinese herbal medicine were ob-tained.Through enrichment analysis,10 relevant pathways and 3 core pathways were obtained with the involvement of 127 BP,27 CC,and 43 MF.CONCLUSION:There are multiple targets and sig-naling pathways are involved in the action of CHSGS in the treatment of MDD.
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