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目的研究恶性间皮瘤的临床特点、病理学形态、免疫表型及鉴别诊断。方法对100例恶性间皮瘤的临床资料、病理学形态及免疫组化进行总结与分析,并探讨其鉴别诊断。结果恶性间皮瘤男性较女性多见,平均年龄53岁,病变部位广泛,临床症状无特异性。肿瘤组织学形态复杂,组织排列多变,细胞形态多样。免疫组化:calretinin(93/100)、CK5/6(63/79)、D2-40(24/37)和WT-1(8/17)(+)。结论恶性间皮瘤的诊断需结合临床资料、以病理形态为主并结合免疫组化结果综合考虑,但要重视鉴别诊断。
Objective To study the clinical features, pathological morphology, immunophenotype and differential diagnosis of malignant mesothelioma. Methods 100 cases of malignant mesothelioma clinical data, pathological morphology and immunohistochemistry were summarized and analyzed, and to explore the differential diagnosis. Results Malignant mesothelioma was more common in women than in women, with an average age of 53 years. The lesions were extensive and the clinical symptoms were not specific. Tumor histology is complex, the arrangement of tissues is varied, and the cell morphology is diverse. Immunohistochemistry: calretinin (93/100), CK5 / 6 (63/79), D2-40 (24/37) and WT-1 (8/17) (+). Conclusion The diagnosis of malignant mesothelioma need to be combined with clinical data, with pathological morphology and immunohistochemistry combined results, but should pay attention to differential diagnosis.