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目的探讨阴茎鳞状细胞癌的特殊类型疣状癌的诊断和治疗方法。方法回顾性分析8例阴茎疣状癌患者的诊治资料。患者平均年龄46岁。肿瘤均为菜花状、外生型,最大径2～6cm,局限于阴茎头5例,侵犯至冠状沟近侧3例。经活检病理诊断后,3例肿瘤侵犯冠状沟近侧者和1例位于阴茎头肿瘤较大者行阴茎部分切除术,4例局限于阴茎头者行肿瘤局部切除术。结果病理检查见肿瘤细胞分化好,标本切缘均阴性。1例肿瘤局部切除术者术后14个月阴茎残端复发,再行阴茎部分切除术,术后随访9年,无肿瘤复发或转移。其余7例术后随访4～13年,均无肿瘤复发或转移。肿瘤局部切除术者术后性生活较满意。结论阴茎疣状癌的生物学行为以局部侵袭性生长为主,很少发生区域性淋巴结转移或远处转移,采用恰当的治疗方法后患者预后好。
Objective To investigate the diagnosis and treatment of specific types of penile squamous cell carcinoma of the penis. Methods The clinical data of 8 cases of penile verrucous carcinoma were retrospectively analyzed. The average age of patients was 46 years old. The tumors were cauliflower-like, exophytic, the maximum diameter of 2 ~ 6cm, confined to the first glans penis 5, violations of the proximal coronal groove in 3 cases. After the biopsy pathological diagnosis, 3 cases of tumor invasion of the proximal coronal and 1 case of penis tumor located in the greater part of the penis partial resection, 4 cases limited to the penis head tumor resection. Results The pathological examination showed that the tumor cells were well differentiated and all the specimens were negative. One case of tumor partial resection 14 months after the penis stump recurrence, and then the penis partial resection, followed up for 9 years, no tumor recurrence or metastasis. The remaining 7 cases were followed up for 4 to 13 years, no tumor recurrence or metastasis. Tumor resection of postoperative sex life more satisfied. Conclusions The biological behavior of penile verrucous carcinoma is predominantly localized invasive growth, and rarely occurs in regional lymph node metastasis or distant metastasis. The prognosis is good after proper treatment.