The effect of a guide vane installed at the elbow on flow-induced noise and vibration is investigated in the range of Reynolds numbers from 1.70×105 to 6.81×105, and the position of guide vane is determined by publications. The turbulent flow in the piping elbow is simulated with large eddy simulation(LES). Following this, a hybrid method of combining LES and Lighthill’s acoustic analogy theory is used to simulate the hydrodynamic noise and sound sources are solved as volume sources in code Actran. In addition, the flow-induced vibration of the piping elbow is investigated based on a fluid-structure interaction(FSI) code. The LES results indicate that the range of vortex zone in the elbow without the guide vane is larger than the case with the guide vane, and the guide vane is effective in reducing flow-induced noise and vibration in the 90° piping elbow at different Reynolds numbers. The effect of a guide vane installed at the elbow on flow-induced noise and vibration is investigated in the range of Reynolds numbers from 1.70 × 105 to 6.81 × 105, and the position of guide vane is determined by publications. The turbulent flow in the piping elbow is simulated with large eddy simulation (LES). Following this, a hybrid method of combining LES and Lighthill’s acoustic analogy theory is used to simulate the hydrodynamic noise and sound sources are solved as volume sources in code Actran. In addition, the flow -induced vibration of the piping elbow is investigated based on a fluid-structure interaction (FSI) code. The LES results indicate that the range of vortex zone in the elbow without the guide vane is larger than the case with the guide vane, and the guide vane is effective in reducing flow-induced noise and vibration in the 90 ° piping elbow at different Reynolds numbers.