观察硫胺素与甘草酸二铵治疗慢性乙型肝炎的临床疗效。在美国加州及大连分别对慢性乙型肝炎患者应用硫胺素和甘草酸二铵。甘草酸二铵组与甘草酸二铵 +硫胺素组肝功复常率两组间有显著差异 ;硫铵素组与上述两组比较肝功复常率明显降低 ,差异显著。硫铵素组连续用药 4 8周后 ,肝功复常率、血清HBVDNA、HBeAg阴转率与治疗第八周结束时各治疗组比较有显著差异。硫铵素可降低乙肝病毒含量 ,稳定肝脏内环境 ,促进肝功恢复 To observe the clinical efficacy of thiamine and diammonium glycyrrhizinate in the treatment of chronic hepatitis B. Thiamine and diammonium glycyrrhizinate were administered to patients with chronic hepatitis B in California and Dalian respectively. Glycyrrhizic acid diammonium and glycyrrhizic acid diammonium + thiamine group of liver function was significantly different between the two groups; ammonium sulfate group and the above two groups was significantly lower rate of liver function, significant difference. After 48 weeks of continuous administration of ammonium sulfate group, the rates of normal liver function, serum HBVDNA and HBeAg negative rate were significantly different from those of the treatment groups at the end of the eighth week of treatment. Thiamin can reduce the content of hepatitis B virus, stabilize the liver’s internal environment and promote the recovery of liver function