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近年在美国妊娠期非法有害物质如可卡因及大麻的应用范围及数量急剧增加,为研究这些物质对胎儿的影响,对美国7所大学,产科检查中孕23～26周的7470例进行观察。 方法:通过对7470例孕妇询问用药史及放射免疫检测血清中可卡因及大麻的代谢产物苯甲酰芽子碱及THC-COOH。同时观察用药与未用药孕妇低出生体重儿和早产儿的发生率,及体内代谢产物的浓度与低出生体重儿及早产儿的关系(低出生体重儿:出生体重<2500g;早产儿:孕周<37周者)。 结果;①妊娠期间应用可卡因与低出生体重儿及早产儿无关。应用可卡因的孕妇和未用药者低出
In recent years, the scope and number of illicit substances such as cocaine and marijuana during pregnancy in the United States have dramatically increased. In order to study the impact of these substances on the fetus, 7470 pregnant women at 23-26 weeks of gestation in 7 American universities and obstetric examinations were observed. Methods: 7470 pregnant women were asked about drug use history and radioimmunoassay to detect the metabolites benzocaine and THC-COOH, which are the metabolites of cocaine and marijuana in serum. At the same time, we observed the incidence of low birth weight infants and premature infants in pregnant women with or without medication, and the relationship between the body metabolites and low birth weight infants and premature infants (low birth weight infants: birth weight <2500g; premature infants: gestational age < 37 weeks). Results ① The use of cocaine during pregnancy has nothing to do with low birth weight infants and premature infants. Pregnant women and nonusers who use cocaine are lower