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目的:观察米索前列醇对子宫宫颈的软化作用,比较米索前列醇在无痛人工流产手术中对麻醉效果和手术操作的影响。方法:将120例首次怀孕妇女随机分成两组,观察组手术前1h舌下含服米索前列醇400μg软化宫颈;对照组手术前不使用任何药物。使用丙泊酚静脉麻醉后手术,观察两组不同条件下的宫颈情况,及对手术操作和麻醉效果的影响。结果:观察组96.67%的患者手术扩张宫颈过程顺利,扩宫及手术用时短;丙泊酚用药量少,平均用药量(111.86±3.96)mg,麻醉过程血压、心率平稳,无呼吸抑制出现。对照组80.00%的患者需扩宫棒依次扩宫,扩宫困难,扩宫及手术用时长,丙泊酚用药量多,平均用药量(189.59±9.41)mg。麻醉过程血压、心率波动大,患者身体多躁动,其中6例出现呼吸抑制,需麻醉面罩加压给氧,控制呼吸。两组各组数据对比,差异有统计学意义(P<0.05)。结论:无痛人工流产术前舌下含服米索前列醇,应用简便,能有效软化子宫宫颈,是安全、有效的药物扩宫方法。
OBJECTIVE: To observe the effect of misoprostol on uterine cervix softening and to compare the effects of misoprostol on anesthesia and surgical procedures in painless induced abortion. Methods: One hundred and twenty first-time pregnant women were randomly divided into two groups. The observation group received sublingual misoprostol 400μg subcutaneously before cervix 1h and the control group did not use any drugs before surgery. Intravenous anesthesia with propofol was performed to observe the effects of different conditions on the cervix, operation and anesthesia. Results: In the observation group, 96.67% of the patients underwent surgical dilatation and cervical splenectomy. The propofol was used in a small amount and the average dosage was (111.86 ± 3.96) mg. The blood pressure and heart rate during anesthesia were stable without respiratory depression. 80.00% of the patients in the control group needed to expand the gonad, followed by dilation of the gonad, expansion of the dilation and operation, prolonged use of propofol and average dosage of 189.59 ± 9.41 mg. Anesthesia process of blood pressure, heart rate fluctuations, the patient more agitation, of which 6 cases of respiratory depression, anesthesia mask to be pressurized oxygen, control of breathing. The two groups of data comparison, the difference was statistically significant (P <0.05). Conclusion: Analgesic induced abortion preoperative sublingual misoprostol, easy to use, can effectively soften the uterine cervix, is a safe and effective drug dilation method.