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目的 探讨血清铁在严重急性呼吸综合征 (SARS)患者血清中的改变及临床意义。方法 用铁络合方法检测 6 0例发病早期 (1～ 7d)、2 5例发病 1周后SARS患者以及 19例排除SARS病人血清铁 (Fe)水平 ,同时与白细胞 (WBC)和淋巴细胞绝对值(LYM)比较。结果 确诊SARS病人 ,在发病 1周内有 72 %患者Fe明显低于排除SARS组、正常对照组及肝病组 ,t检验有显著性差异。以 7.2 μmol/L为临界值时 ,诊断敏感性为 6 7.4 %、诊断特异性为 6 9.2 % ,阳性预示值为 91.9%。发病 1周后大多数SARS患者Fe水平恢复正常。Fe水平、LYM水平在SARS患者发病早期即下降 ,当以其正常参考范围低限为界值时 ,敏感性分别为 72 %和 75 %。WBC在SARS患者发病早期大多数都在正常参考范围。三项指标的改变无相关性。结论 Fe和LYM分别低于 7.2 μmol/L和 1.5× 10 9/L ,是SARS早期的重要实验室改变
Objective To investigate the changes of serum iron in serum of patients with severe acute respiratory syndrome (SARS) and its clinical significance. Methods The iron complex method was used to detect serum iron (Fe) levels in 60 patients with SARS (early stage 1 ~ 7d), 25 patients with SARS after 1 week and 19 patients with SARS. Value (LYM) comparison. The results of the diagnosis of SARS patients, within a week of onset of 72% of patients with Fe was significantly lower than excluding SARS group, normal control group and liver disease group, t test was significantly different. At 7.2 μmol / L cutoff, the diagnostic sensitivity was 6 7.4%, the diagnostic specificity was 6.22%, and the positive predictive value was 91.9%. Most patients with SARS returned to normal levels of Fe after 1 week of onset. Fe levels, LYM levels in the early onset of SARS patients that decline, when the lower limit of its normal reference range for the threshold, the sensitivity was 72% and 75%. The majority of WBCs are in the normal reference range in the early stages of SARS. No change in the three indicators. Conclusions Fe and LYM are lower than 7.2 μmol / L and 1.5 × 10 9 / L, respectively, which is an important laboratory change in SARS