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目的分析永康市2000～2011年新生儿先天性甲状腺功能减低症(CH)和苯丙酮尿症(PKU)筛查结果,探讨永康市两病的发生情况,促进并完善新生儿疾病筛查工作,为制定干预措施提供依据。方法新生儿娩出满72h并吃足6次奶后,采集婴儿足跟内、外侧缘末梢血制成血片,将合格血片递送到浙江省新生儿疾病筛查中心进行CH、PKU检测。结果 12年共筛查新生儿74 149例,筛查率92.77%;检出CH47例,发病率为1/1578;检出PKU6例,发病率为1/12 358。结论永康市新生儿CH及PKU的发病率与浙江省平均水平相似,开展新生儿疾病筛查,早期发现CH和PKU的患儿,尽早对其进行干预,对避免或减轻新生儿智力和体格发育落后,提高我市人口素质具有重大意义。
Objective To analyze the screening results of neonatal congenital hypothyroidism (CH) and phenylketonuria (PKU) from 2000 to 2011 in Yongkang City, and to explore the occurrence of the two diseases in Yongkang City, to promote and perfect the screening of neonatal diseases, Provide the basis for making interventions. Methods After the newborn was delivered for 72h and fed for 6 times, the blood was collected from the peripheral blood of the heel and lateral margin of the infant to deliver the qualified blood film to the Center for Neonatal Disease Screening in Zhejiang Province for CH and PKU detection. Results A total of 74 149 newborns were screened at 12 years. The screening rate was 92.77%. The number of CH47 cases was detected at a rate of 1/1578. PKU was detected in 6 cases and the incidence rate was 1/12 358. Conclusions The incidence of neonatal CH and PKU in Yongkang is similar to that of Zhejiang Province. To carry out neonatal screening and early detection of CH and PKU in children, we should intervene as soon as possible to avoid or alleviate neonatal mental and physical development Backward, improve the quality of the city’s population of great significance.