论文部分内容阅读
对免疫球蛋白基因超突变的分析让人们对各种B细胞及其肿瘤发生发展有了更深刻的认识。目前公认的是,生发中心前B细胞不含体细胞超突变,而生发中心B细胞和生发中心后B细胞(记忆性B细胞和浆细胞)表现出体细胞超突变。如果肿瘤性B细胞的免疫球蛋白超突变存在于肿瘤的发展中,那么连续获得的突变有可能导致肿瘤细胞行为的改变。一些原癌基因:bc l-6,bc l-2,c-myc也可发生体细胞超突变,与各种恶性淋巴瘤的发生相关联。对上述基因的体细胞超突变机制的共性以及它们相互之间是否有关联尚在深入研究中。
Analysis of hyperstimulation of immunoglobulin genes has given people a deeper understanding of the development of various B cells and their tumors. It is currently accepted that pre-B cells do not contain somatic hypermutations, whereas somatic B cells and germinal center B cells (memory B cells and plasma cells) exhibit somatic hypermutations. If the immunoglobulin hypermutation of neoplastic B cells is present in the development of a tumor, successive mutations are likely to result in changes in tumor cell behavior. Some oncogenes: bc l-6, bc l-2, c-myc can also occur somatic hypermutation, associated with the occurrence of various malignant lymphomas. The generality of the somatic hypermutation mechanisms of these genes and whether they are related to each other are still under study.