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目的探讨安徽省安庆地区卡波肉瘤相关疱疹病毒(KSHV)在普通人群中的感染情况,并初步分析KSHV感染的危险因子。方法选择KSHV ORF65、ORF73和K8.1编码的病毒蛋白为抗原,采用酶联免疫法对1 006份普通健康人群血清进行KSHV抗体检测。结果在检测的1 006份血样中,KSHV抗体的总阳性率为5.3%,其中男性为5.6%,女性为5.5%。KSHV感染率与梅毒感染有显著相关性,但是其与年龄、性别、血型及乙肝五项间无明显相关性。结论中国安徽安庆地区的普通健康人群KSHV的感染率较低,其中KSHV的感染率与性病梅毒感染具有显著相关性。
Objective To investigate the prevalence of Kaposi’s sarcoma-associated herpesvirus (KSHV) in the general population in Anqing, Anhui Province and to analyze the risk factors of KSHV infection. Methods The viral proteins encoded by KSHV ORF65, ORF73 and K8.1 were selected as antigen. ELISA was used to detect the KSHV antibody in serum of 1006 common healthy people by enzyme-linked immunosorbent assay. Results The total positive rate of KSHV antibody was 5.3% in the 1 006 blood samples tested, with 5.6% in males and 5.5% in females. There was a significant correlation between KSHV infection rate and syphilis infection, but there was no significant correlation between KSHV infection rate and age, gender, blood type and HBV. Conclusion The prevalence of KSHV is lower in general healthy people in Anqing, Anhui Province of China. The infection rate of KSHV is significantly correlated with the infection of STDs.