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目的 :探讨血浆内皮素在糖尿病并发心血管疾病中的作用。方法 :采用放射免疫分析法测定了34例糖尿病患者 ,2 7例糖尿病并发心血管病患者及 30例正常健康人血浆中的内皮素的含量。结果 :糖尿病组血浆内皮素含量显著高于正常对照组 (p <0 .0 1) ,糖尿病并发心血管病组血浆内皮素含量明显高于糖尿病无并发症组 (p <0 .0 1)。结论 :血浆内皮素在糖尿病并发心血管疾病的过程中起着重要作用 ,可以作为早期发现糖尿病心血管并发症的敏感指标之一
Objective: To investigate the role of plasma endothelin in diabetic patients with cardiovascular diseases. Methods: The plasma levels of endothelin in 34 patients with diabetes mellitus, 27 patients with diabetes mellitus and 30 normal controls were measured by radioimmunoassay. Results: The plasma endothelin level in diabetic group was significantly higher than that in normal control group (p <0.01). The plasma endothelin level in diabetic patients with cardiovascular disease group was significantly higher than that in non-diabetic diabetic group (p <0.01). Conclusion: Plasma endothelin plays an important role in the pathogenesis of diabetes mellitus and cardiovascular disease and may be used as one of the sensitive indicators for the early detection of cardiovascular complications of diabetes mellitus