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目的:研究三阴性及非三阴性乳腺癌中血管内皮生长因子-C(VEGF-C)的表达及临床意义。方法:采用EnVision法对三阴性乳腺癌、非三阴性乳腺癌及癌旁正常组织标本进行VEGF-C的免疫组织化学染色,观察VEGF-C表达及与临床病理特点之间的关系。结果:VEGF-C在三阴性乳腺癌中高表达,阳性表达率30%(9/30);VEGF-C在非三阴性乳腺癌中更高表达,阳性表达率80%(20/25);VEGF-C在癌旁组织中不表达(0/10),阳性率的比较差异有显著性(P<0.05)。三阴性乳腺癌中VEGF-C表达与患者的年龄、月经状态、肿瘤大小、淋巴结状态、分期无关(P>0.05)。非三阴性乳腺癌中VEGF-C表达与患者的年龄、月经状态、肿瘤大小、分期无关(P>0.05),而与淋巴结状态有关(P<0.05)。结论:VEGF-C的表达可能在促进非三阴性乳腺癌淋巴结转移中起作用。
Objective: To investigate the expression and clinical significance of vascular endothelial growth factor-C (VEGF-C) in triple-negative and non-negative-negative breast cancers. METHODS: EnVision immunohistochemical staining of VEGF-C was performed on specimens of triple-negative breast cancer, non-negative breast cancer, and adjacent normal tissues. The relationship between VEGF-C expression and clinicopathological features was observed. RESULTS: VEGF-C was highly expressed in triple-negative breast cancer, with a positive expression rate of 30% (9/30); VEGF-C was more highly expressed in non-triple negative breast cancer, with a positive expression rate of 80% (20/25); VEGF -C was not expressed in adjacent tissues (0/10), and the positive rate was significantly different (P < 0.05). The expression of VEGF-C in triple negative breast cancer was not related to the age, menstrual status, tumor size, lymph node status and stage (P>0.05). The expression of VEGF-C in non-triple negative breast cancer was not related to age, menstrual status, tumor size, and stage (P>0.05), but was related to lymph node status (P<0.05). Conclusion: The expression of VEGF-C may play a role in promoting lymph node metastasis in non-negative breast cancer.