类风湿关节炎(RA)是一种慢性进展性炎症性疾病,能引起关节破坏、早期致残。传统RA治疗采用金字塔式治疗方案,在塔底先用非甾体抗炎药(NSAIDs),然后逐渐进展到塔尖的所谓的控制病情药物(DMARD)。NSAIDs通过抑制前列腺素合成,减轻疼痛和炎症,虽然起效快,但它们对疾病本身影响小, Rheumatoid arthritis (RA) is a chronic, progressive inflammatory disease that causes joint destruction and early disability. Traditional RA therapies employ a pyramidal treatment that uses non-steroidal anti-inflammatory drugs (NSAIDs) at the base of the column and then progresses to the spiked so-called DMARD. By inhibiting prostaglandin synthesis and relieving pain and inflammation, NSAIDs, while acting fast, have little effect on the disease itself,