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癌症的化疗与放疗,常致恶心与呕吐,远比其他副作用更影响病人的生活质量。呕吐引起脱水、代谢紊乱、手术缝线断裂、营养不良,继而需胃肠外给养,严重者不得不停止治疗。胃酸分泌随迷走神经的控制而周期性变化,睡眠时胃肠蠕动慢,肛门括约肌反射改变,吞咽活动弱,唾液分泌近乎于停止,因此,有理由相信睡眠中呕吐反射也会不同。为了解睡眠中给药是否会减少化疗所致的急性恶心与呕吐进行了下述临床实验。选取21例首
Cancer chemotherapy and radiotherapy, often causing nausea and vomiting, affect the patient’s quality of life far more than other side effects. Vomiting causes dehydration, metabolic disorders, broken surgical threads, and malnutrition, which in turn require parenteral feeding. Severe patients have to stop treatment. Gastric acid secretion changes periodically with the control of the vagus nerve, slow gastrointestinal motility during sleep, altered anal sphincter reflexes, weak swallowing activity, and near-stop salivation. Therefore, there is reason to believe that vomiting reflections during sleep will be different. The following clinical trials were conducted to understand whether administration during sleep would reduce acute nausea and vomiting caused by chemotherapy. Select 21 cases