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众所周知，阻滞电压依赖性Na＋通道的药物有局部麻醉药、抗心律失常药和抗惊厥药。最近的研究表明，这些化合物在脑缺血、低氧和头部创伤的动物模型中也提供了有效的细胞保护机制。木文综述Na＋通道阻滞剂神经保护作用的证据和提出电压依赖性Na＋通道阻滞剂分子作用位点的新论点。几种药物目前正在进行中风和头部外伤的临床研究。作者对这些药物的治疗潜力进行了讨论。
It is well known that drugs that block voltage-dependent Na + channels include local anesthetics, antiarrhythmic drugs, and anticonvulsants. Recent studies have shown that these compounds also provide an effective cytoprotective mechanism in animal models of cerebral ischemia, hypoxia and head trauma. Wood Review: Evidence for Neuroprotective Effects of Na + Channel Blockers and New Arguments for the Role of Molecular Pathways in Voltage-Dependent Na + Channel Blockers. Several drugs are currently undergoing clinical studies of stroke and head trauma. The authors discuss the therapeutic potential of these drugs.