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穿孔素(perforin)是T杀仿细胞和自然杀伤细胞颗粒中的一种蛋白质,能使靶细胞膜溶解形成孔状病变。穿孔素的杀伤机理类似于补体激活过程中某些终末成份的作用机理。氨基酸顺序分析表明,穿孔素与补体C9届同一类。
Perforin is a protein in T-like and natural killer cell particles that dissolves the target cell membrane to form cellular lesions. The mechanism of perforin killing is similar to the mechanism of action of certain terminal components during complement activation. Amino acid sequence analysis showed that perforin and complement C9 session of the same class.