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目的优选薄膜-超声法制备双烟酸姜黄素酯固体脂质纳米粒的辅料配比。方法采用HPLC测定双烟酸姜黄素酯的含量,以双烟酸姜黄素酯固体脂质纳米粒的包封率为评价指标,通过三因素三水平Box-Bebnken响应面设计试验法筛选纳米粒辅料中硬脂酸、卵磷脂的用量及聚山梨酯-80的浓度,并确定最优处方辅料配比。结果最佳处方辅料配比为硬脂酸80 mg,卵磷脂150 mg,聚山梨酯-80(0.6%)20 m L,所得烟酸姜黄素固体脂质纳米粒包封率达65%,平均粒径为190 nm。结论用星点设计试验优化后制剂处方的双烟酸姜黄素酯固体脂质纳米粒最优处方辅料配比适合于制备双烟酸姜黄素酯固体脂质纳米粒。
Objective To optimize the preparation of the film of double - nicotinic acid curcumin ester solid lipid nanoparticles by thin film - ultrasonic method. Methods HPLC was used to determine the content of curcumin and the entrapment efficiency of curcumin bis-nicotinate solid lipid nanoparticles was evaluated by Box-Bebnken response surface design of three factors and three levels. Stearic acid, the amount of lecithin and polysorbate-80 concentration, and to determine the optimal prescription materials ratio. Results The optimal formulation prescriptions were 80 mg of stearic acid, 150 mg of lecithin and 20 mL of polysorbate-80 (0.6%). The entrapment efficiency of curcumin solid lipid nanoparticles was 65% The particle size is 190 nm. Conclusions The optimal formulation and prescription of curcumin bispyridinate solid lipid nanoparticles with prescriptions of galactosidase and solid prescription is better than that of curcumin and bisulfonic acid ester solid lipid nanoparticles.