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目的 :通过对单次静注氯胺酮 (Ket)的定量脑电图 (qEEG)分析来进一步加深认识此药的麻醉性能 ,探求可以反映其麻醉深度的指标。方法 :9例ASAⅠ～Ⅱ级 ,年龄 2 2～ 2 7岁 ,Ket 4mg/kg单次静脉注射 ,分术前、ket静注后第 5分钟及第 2 0分钟三个时段作qEEG监测并采集各项参数值 ,行前后自身对照。结果 :①REL :可见术前各导联均以α波为主 ,θ波成份最小。但给药后 5分钟却完全以θ波为主 ,至第 2 0分钟仍以θ波为主。②δ比率 :术前处于低比率状态 ,给药 5分钟后比率显著上升 (P <0 0 1 ) ,第 2 0分钟时比率回落 ,其中F7、F8导联已与术前无显著差异。③θ比率 :术前低 ,给药第 5分钟时比率骤升 ,2 0分钟时回落不显著 ,维持时间长于δ比率。而用反θ比率则更能清楚地显示这一特征 ,术前的高比率在给药第 5分钟时骤然崩解 ,第 2 0分钟时略有上升趋势。结论 :EEG持久高功率的θ波活动是单次静注Ket 4mg/kg麻醉的特征表现 ;δ比率的变化趋势能反映患者的临床初醒状态 ,而“θ比率”与“反θ比率”较δ比率能更实际地反映大脑意识变化情况
OBJECTIVE: To further understand the anesthetic properties of this drug through a quantitative intravenous (QEEG) analysis of ketamine (Ket), and explore the indicators that can reflect the depth of anesthesia. Methods: Nine ASA Ⅰ ~ Ⅱ grade, aged 22 to 27 years, Ket 4mg / kg single intravenous injection before operation, ketamine intravenous injection at the first 5 minutes and 20 minutes for qEEG monitoring and collection The value of the parameter, before and after the line itself control. Results: ①REL: we can see preoperative leads were mainly α wave, θ wave minimum. But after 5 minutes of administration, it is completely based on theta-wave, and the 20th wave is still predominantly theta-wave at the 20th minute. ② The ratio of δ: preoperatively in a low ratio state, the ratio increased significantly after 5 minutes (P <0.01), the ratio of 20 minutes decreased, F7, F8 lead has no significant difference with the preoperative. ③ θ ratio: preoperative low, the ratio of 5 minutes after administration sharp rise, 20 minutes did not fall significantly, maintaining longer than δ ratio. This characteristic was more clearly demonstrated by the anti-theta ratio, with preoperative high rates of disintegration abruptly at 5 minutes of administration and a slight upward trend at 20 minutes. CONCLUSION: The long-term high-power θ-wave activity of EEG is characteristic of a single intravenous injection of Ket 4mg / kg anesthesia. The change trend of δ-ratio reflects the state of patients’ initial awakening, while the ratio of θ and θ δ ratio can more accurately reflect the changes in brain consciousness