间皮素是一种分子量为40kDa的细胞表面糖蛋白,高表达于多种肿瘤组织中,也可表达于正常胸膜、心包和腹膜的间皮细胞中,因而不是肿瘤特异性蛋白。一些间皮素阳性肿瘤患者的血中可以检测到少量间皮素,测定血中的间皮素可能有助于这些患者的诊断[1]。间皮素基因编码一种69kDa的前体 Mesothelin is a 40 kDa molecular weight cell surface glycoprotein that is highly expressed in a variety of tumor tissues and can also be expressed in normal pleural, pericardial and peritoneal mesothelial cells and is therefore not a tumor-specific protein. Some patients with mesothelioma positive tumor blood can detect a small amount of mesothelin, determination of blood mesothelin may contribute to the diagnosis of these patients [1]. The mesothelin gene encodes a 69 kDa precursor