肾上腺皮质激素作为治疗肾小球疾病的主要药物广泛应用于临床 ,但是 ,在急性肾功能衰竭情况下是否使用激素 ,常常是临床医生举棋不定的问题。其原因在于 :(1)肾上腺皮质激素在体内的绝大部分代谢产物及原形经肾脏排泄 ,在肾功能衰竭时可造成药物蓄积 ;(2 )皮质激素对代谢的影响 Corticosteroids are widely used clinically as the primary drug for the treatment of glomerular diseases. However, whether or not to use hormones in acute renal failure is often a clinician’s unsure questions. The reason is that: (1) most of the body’s metabolism and adrenal cortical hormone excretion by the kidneys, renal failure can cause drug accumulation; (2) corticosteroids on the metabolism