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目的探讨连接蛋白37(connexins37,CX37)基因I1297D多态性位点与缺血性脑卒中及其亚型的关系。方法采用限制性片段长度多态性分析技术,检测缺血性脑卒中组232例(根据诊断分为动脉粥样硬化性血栓性脑梗死组115例,脑栓塞组31例,腔隙性脑梗死组86例)和健康对照组235例CX37基因I1297D多态的分布。结果 CX37基因I1297D多态性,缺血性脑卒中组和对照组中均以II基因型和I等位基因为主。基因型(II型I、D型、DD型)I、和D等位基因分布频率在缺血性脑卒中组分别为46.56%、39.22%、14.22%、66.16%和33.84%,对照组分别为47.66%、43.40%、8.94%、69.36%和30.64%,2组比较差异无统计学意义(P>0.05),且其基因型、等位基因分布频率在缺血性脑卒中各亚型之间与对照组比较,差异无统计学意义(P>0.05)。结论 CX37基因I1297D的多态性与缺血性脑卒中易感性无关。
Objective To investigate the relationship between the I1297D polymorphism of Connexins37 (CX37) gene and ischemic stroke and its subtypes. Methods 232 cases of ischemic stroke were detected by restriction fragment length polymorphism (115 cases were classified as atherothrombotic cerebral infarction, 31 cerebral infarction, lacunar infarction Group 86 cases) and healthy control group 235 cases of CX37 gene I1297D polymorphism distribution. Results The I1297D polymorphism of CX37 gene was predominant in both genotype II and I alleles in ischemic stroke group and control group. The distribution frequencies of genotypes (type I, type D and type DD) I and D allele were 46.56%, 39.22%, 14.22%, 66.16% and 33.84% respectively in the ischemic stroke group, while the control group were 47.66%, 43.40%, 8.94%, 69.36% and 30.64%, respectively. There was no significant difference between the two groups (P> 0.05), and the frequency of genotype and allele was between the subtypes of ischemic stroke Compared with the control group, the difference was not statistically significant (P> 0.05). Conclusion The polymorphism of CX37 gene I1297D is not associated with susceptibility to ischemic stroke.