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为了解山莨菪碱及地塞米松对兔多器官功能障碍综合征（ＭＯＤＳ）时微循环变化及对肿瘤坏死因子（ＴＮＦ）、脂质过氧化物（ＬＰＯ）和病理改变的影响，作者将日本大耳兔行盲肠结扎加穿孔（ＣＬＰ）造成腹腔感染，制成ＭＯＤＳ动物模型，随机分为山莨菪碱组、地塞米松组、山莨菪碱及地塞米松组、对照组，用药后观察微循环的变化、ＴＮＦ、ＬＰＯ的变化和组织器官的病理形态学改变。结果显示用药后微循环的灌注量、微循环内红细胞等移动的微粒数量明显增加，实验各组血浆的ＴＮＦ及ＬＰＯ水平均有明显的降低，器官形态学变化较对照组均有不同程度的减轻。以联合用药组变化最突出。提示山莨菪碱及地塞米松联合应用可能是ＭＯＤＳ时改善微循环和抗细胞因子、抗氧自由基治疗的新途径。
To understand the effects of anisodamine and dexamethasone on microcirculation and on tumor necrosis factor (TNF), lipid peroxides (LPO) and pathological changes in multiple organ dysfunction syndrome (MODS) in rabbits, The rabbits were subjected to cecal ligation and perforation (CLP) to induce intraperitoneal infection. Animal models of MODS were established and randomly divided into ananisodal group, dexamethasone group, anisodamine and dexamethasone group, and control group. After treatment, Circulation changes, TNF, LPO changes and histopathological changes. The results showed that the amount of micro-circulation perfusion, the number of red blood cells and other moving micro-particles in the microcirculation significantly increased after treatment, the levels of TNF and LPO in the plasma of the experimental groups were significantly decreased, the morphological changes of the organs were relieved to some extent compared with the control group . The most prominent change in the combination group. Tip combination of anisodamine and dexamethasone MODS may be used to improve microcirculation and anti-cytokines, antioxidant free radical treatment of new ways.