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目的观察伏立康唑治疗血液系统恶性肿瘤并发侵袭性真菌感染的疗效。方法回顾性分析24例血液系统恶性肿瘤并发侵袭性真菌感染患者采用常规剂量的伏立康唑序贯治疗的情况。结果本组24例中1例因疾病进展死亡用药4d自然停药而无法评估,其余23例中痊愈5例,显效11例,无效7例,有效率为69.57%。治疗过程中出现视觉障碍5例,无需停药,均能缓解。肝功能损害2例,经护肝药物治疗后恢复正常。颜面潮红1例,出汗1例,恶心、胃部不适1例,经对症治疗及调整服药时间后好转。结论伏立康唑静脉注射或口服疗效均好,耐受性强,毒副作用轻,是治疗侵袭性真菌感染的有效药物。
Objective To observe the efficacy of voriconazole in the treatment of hematological malignancies complicated with invasive fungal infection. Methods A retrospective analysis of 24 cases of hematological malignancies complicated with invasive fungal infection with conventional doses of voriconazole sequential treatment. Results In the group of 24 cases, one patient died of disease progression and could not be evaluated after 4 days of drug withdrawal. The remaining 23 cases were cured in 5 cases, markedly effective in 11 cases and ineffective in 7 cases, with an effective rate of 69.57%. 5 cases of visual impairment during treatment, without stopping, can ease. Liver damage in 2 cases, after treatment with liver protection returned to normal. 1 case of facial flushing, 1 case of sweating, nausea, stomach discomfort in 1 case, after symptomatic treatment and adjust the medication time improved. Conclusion Voriconazole is an effective drug for the treatment of invasive fungal infections by intravenous injection or oral administration, with good tolerability and light side effects.